Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity

Fowler, Tom Alan, Langley, Kate ORCID: https://orcid.org/0000-0002-2033-2657, Rice, Frances ORCID: https://orcid.org/0000-0002-9484-1729, van den Bree, Marianne Bernadette ORCID: https://orcid.org/0000-0002-4426-3254, Ross, Kenny, Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19 (6) , pp. 312-319. 10.1097/YPG.0b013e3283328df4

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Abstract

Objectives: Psychopathy-related traits, especially those tapping the 'emotional dysfunction' aspect of psychopathy that is characterized by lack of emotional responsiveness, are thought to be of genetic origin, but molecular genetic studies are yet to be undertaken. Gene variants that affect COMT, MAOA and 5HTT activity have previously been linked to antisocial behaviour. The aims of this study were to test whether these gene variants are linked to psychopathy traits in attention-deficit hyperactivity disorder (ADHD). Methods: Adolescents were followed up 5 years after an initial diagnosis of ADHD. Psychopathy trait scores were assessed [total scores and 'emotional dysfunction' (also referred to as 'affective') scores] and the MAOA 30-bp variable number of tandem repeats, SLC6A4 44-bp insertion/deletion and COMT Val158Met variants were genotyped. Results: All three gene variants were associated with 'emotional dysfunction' scores. MAOA and 5HTT variants were associated with total psychopathy scores. The results were not explained by associated conduct disorder. Conclusion: The results suggest that specific gene variants influence psychopathy traits in ADHD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RJ Pediatrics
Uncontrolled Keywords:	adolescent; antisocial behaviour; attention-deficit hyperactivity disorder; child; COMT; genetics; 5HTT; MAOA; psychopathy
Publisher:	Lippincott Williams & Wilkins
ISSN:	0955-8829
Last Modified:	06 Nov 2022 14:19
URI:	https://orca.cardiff.ac.uk/id/eprint/29183

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