Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells

Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Dolton, Garry Michael, Matthews, Reginald James and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184 (2) , pp. 607-614. 10.4049/jimmunol.0804089

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Abstract

Although CD8+ T cells are usually considered antitumoral, several recent studies report that the cells can also promote tumor progression. Using the melanoma cell line B16 as a murine model of pulmonary metastasis, we examined whether the pro- versus antitumoral effects of CD8+ T cells relate to their Ag specificity. Results of the study indicate that although CD8+ T cells specific for tumor Ags promote tumor rejection, CD8+ T cells specific for unrelated Ags promote tumor progression. We found the effect to be partly attributable to CD8+ T cells dampening effective antitumor NK cell responses. Notably, activation of CD8+ T cell responses by an unrelated stimulus, in this case infection with influenza virus, increased the number of pulmonary tumor nodules. These data provide a rationale for previously unexplained data identifying contrasting roles for CD8+ T cells in tumor progression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Last Modified:	04 Mar 2023 02:48
URI:	https://orca.cardiff.ac.uk/id/eprint/29594

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