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The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice

Hu, Changyun, Du, Wei, Zhang, Xiaojun, Wong, Florence Susan and Wen, Li 2012. The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice. The Journal of Immunology 188 (1) , pp. 294-301. 10.4049/jimmunol.1101590

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Abstract

Studies suggest that Gr1+CD11b+ cells have immunoregulatory function, and these cells may play an important role in autoimmune diseases. In this study, we investigated the regulatory role of Gr1+CD11b+ cells in protecting against type 1 diabetes in NOD mice. In this study, we showed that temporary B cell depletion induced the expansion of Gr1+CD11b+ cells. Gr1+CD11b+ cells not only directly suppress diabetogenic T cell function but also can induce regulatory T cell differentiation in a TGF-β–dependent manner. Furthermore, we found that Gr1+CD11b+ cells could suppress diabetogenic CD4 and CD8 T cell function in an IL-10–, NO-, and cell contact-dependent manner. Interestingly, single anti-Gr1 mAb treatment can also induce a transient expansion of Gr1+CD11b+ cells that delayed diabetes development in NOD mice. Our data suggest that Gr1+CD11b+ cells contribute to the establishment of immune tolerance to pancreatic islet autoimmunity. Manipulation of Gr1+CD11b+ cells could be considered as a novel immunotherapy for the prevention of type 1 diabetes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: American Association of Immunologists
ISSN: 0022-1767
Last Modified: 04 Jun 2017 03:58
URI: http://orca.cf.ac.uk/id/eprint/29886

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