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New findings from genetic association studies of schizophrenia

Williams, Hywel John, Owen, Michael John and O'Donovan, Michael Conlon 2009. New findings from genetic association studies of schizophrenia. Journal of Human Genetics 54 (1) , pp. 9-14. 10.1038/jhg.2008.7

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Abstract

In the past 20 years, association studies of schizophrenia have evolved from analyses in lesser than 100 subjects of one or two markers in candidate genes to systematic analyses of association at a genome-wide level in samples of thousands of subjects. During this process, much of the emergent literature has been difficult to interpret and definitive findings that have met with universal acceptance have been elusive, largely because studies have been underpowered for such conclusions to be drawn. Nevertheless, in the course of the past few years, a few promising candidate genes have been reported for which the evidence is positive across multiple studies, and more recently, genome-wide association studies have yielded findings of a compelling nature. It is clear that genetic studies in schizophrenia have borne fruit, a process that can be expected to accelerate in the next few years, and that these findings are providing new avenues for research into the pathophysiology of this poorly understood disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
Publisher: Nature Publishing Group
ISSN: 1434-5161
Last Modified: 17 Jan 2020 08:57
URI: http://orca.cf.ac.uk/id/eprint/30032

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