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The molecular basis for public T-cell responses?

Venturi, Vanessa, Price, David, Douek, Daniel C. and Davenport, Miles P. 2008. The molecular basis for public T-cell responses? Nature Reviews Immunology 8 (3) , pp. 231-238. 10.1038/nri2260

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Abstract

Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are observed to dominate the response to the same antigenic epitope in multiple individuals, have long been a focus of immune T-cell repertoire studies. However, the mechanism that enables the survival of a specific TCR from the diverse repertoire produced in the thymus through to its involvement in a public immune response remains unclear. In this Opinion article, we propose that the frequency of production of T cells bearing different TCRs during recombination has an important role in the sharing of TCRs in an immune response, with variable levels of 'convergent recombination' driving production frequencies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: Nature Publishing Group
ISSN: 1474-1733
Last Modified: 19 Mar 2018 15:24
URI: http://orca.cf.ac.uk/id/eprint/30329

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