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Perirhinal cortex lesions uncover subsidiary systems in the rat for the detection of novel and familiar objects

Albasser, Mathieu M., Amin, Eman, Iordanova, Mihaela D., Brown, Malcolm W., Pearce, John Martindale and Aggleton, John Patrick 2011. Perirhinal cortex lesions uncover subsidiary systems in the rat for the detection of novel and familiar objects. European Journal of Neuroscience 34 (2) , pp. 331-342. 10.1111/j.1460-9568.2011.07755.x

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Abstract

The present study compared the impact of perirhinal cortex lesions on tests of object recognition. Object recognition was tested directly by looking at the preferential exploration of novel objects over simultaneously presented familiar objects. Object recognition was also tested indirectly by presenting just novel objects or just familiar objects, and recording exploration levels. Rats with perirhinal cortex lesions were severely impaired at discriminating a novel object from a simultaneously presented familiar object (direct test), yet displayed normal levels of exploration to novel objects presented on their own and showed normal declines in exploration times for familiar objects that were repeatedly presented (indirect tests). This effective reduction in the exploration of familiar objects after perirhinal cortex lesions points to the sparing of some recognition mechanisms. This possibility led us to determine whether rats with perirhinal cortex lesions can overcome their preferential exploration deficits when given multiple object familiarisation trials prior to that same (familiar) object being paired with a novel object. It was found that after multiple familiarisation trials, objects could now successfully be recognised as familiar by rats with perirhinal cortex lesions, both following a 90-min delay (the longest delay tested) and when object recognition was tested in the dark after familiarisation trials in the light. These latter findings reveal: (i) the presumed recruitment of other regions to solve recognition memory problems in the absence of perirhinal cortex tissue; and (ii) that these additional recognition mechanisms require more familiarisation trials than perirhinal-based recognition mechanisms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: habituation; hippocampus; learning; perirhinal cortex; recognition memory
Publisher: Wiley
ISSN: 0953-816X
Last Modified: 09 Mar 2018 20:15
URI: http://orca.cf.ac.uk/id/eprint/30364

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