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The role of the right pre-supplementary motor area in stopping action: two studies with event-related transcranial magnetic stimulation

Cai, W., George, J. S., Verbruggen, Frederick, Chambers, Christopher D. and Aron, A. R. 2012. The role of the right pre-supplementary motor area in stopping action: two studies with event-related transcranial magnetic stimulation. Journal of Neurophysiology 108 (2) , pp. 380-389. 10.1152/jn.00132.2012

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Abstract

Rapidly stopping action engages a network in the brain including the right pre-supplementary motor area (preSMA), the right inferior frontal gyrus and the basal ganglia. Yet the functional role of these different regions within the overall network still remains unclear. Here we focused on the role of the right preSMA in behavioral stopping. We hypothesized that the underlying neurocognitive function of this region is one or more of setting up a stopping rule in advance, modulating response tendencies (e.g. slowing down in anticipation of stopping), and implementing stopping when the stop signal occurs. We performed two experiments with MRI-guided, event-related, transcranial magnetic stimulation (TMS), during the performance of variants of the stop-signal. In Experiment 1 we show that stimulation of the right preSMA vs. vertex (control site) slowed the implementation of stopping (measured via stop signal reaction time) but had no influence on modulation of response tendencies. In Experiment 2, we showed that stimulation of the right preSMA slowed implementation of stopping in a mechanistically selective form of stopping but had no influence on setting up stopping rules. The results go beyond the replication of prior findings in showing that TMS of the right preSMA impairs the stopping process, including a selective form of stopping, by specifically disrupting implementation of the stop process. Future studies are required to establish whether this was due to stimulation of the right preSMA itself or because of remote effects on the wider stopping network.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: dorsomedial frontal cortex; cognitive control; selective stopping; stop signal reaction time; conditional stop signal task
Publisher: American Physiological Society
ISSN: 0022-3077
Last Modified: 04 Jun 2017 04:02
URI: http://orca.cf.ac.uk/id/eprint/31307

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