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Prefrontal and midline interactions mediating behavioural control

Fassbender, Catherine, Hester, Robert, Murphy, Kevin, Foxe, John J., Foxe, Deirdre M. and Garavan, Hugh 2008. Prefrontal and midline interactions mediating behavioural control. European Journal of Neuroscience 29 (1) , pp. 181-187. 10.1111/j.1460-9568.2008.06557.x

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Abstract

Top-down control processes are thought to interact with bottom-up stimulus-driven task demands to facilitate the smooth execution of behaviour. Frontal and midline brain areas in humans are believed to subserve these control processes but their distinct roles and the interactions between them remain to be fully elucidated. In this functional magnetic resonance imaging (fMRI) study, we utilized a GO/NO-GO task with cued and uncued inhibitory events to investigate the effect of cue-induced levels of top-down control on NO-GO trial response conflict. We found that, on a within-subjects, trial-for-trial basis, high levels of top-down control, as indexed by left dorsolateral prefrontal activation prior to the NO-GO, resulted in lower levels of activation on the NO-GO trial in the pre-supplementary motor area. These results suggest that prefrontal and midline regions work together to implement cognitive control and reveal that intra-subject variability is reflected in these lateral and midline interactions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Physics and Astronomy
Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: anterior cingulate cortex; cognitive control; dorsolateral prefrontal cortex; fMRI; human; pre-supplementary motor area
Publisher: Wiley
ISSN: 0953-816X
Last Modified: 08 May 2019 14:04
URI: http://orca.cf.ac.uk/id/eprint/31328

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