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Diabetic peripheral neuropathy: evaluation of the association between neuropathic symptoms (NTSS-6-SA) and health related utility (EQ5D)

Currie, Craig, Covington, M., McEwan, P., Price, Patricia Elaine, Morgan, Christopher L., Cawley, S. and Peters, J. R. 2005. Diabetic peripheral neuropathy: evaluation of the association between neuropathic symptoms (NTSS-6-SA) and health related utility (EQ5D). Value In Health 8 (6) , A172-A173.

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OBJECTIVE: Diabetic peripheral neuropathy (DPN) is a debilitating complication of diabetes and causes sensory symptoms that impact health and functionality. The purpose of this study was to test the hypothesis that there was a direct association between the symptoms associated with DPN (SDPN), as measured by a new instrument the Neuropathy Total Symptom Score (NTSS-6 [self administered]), and health-related utility as measured by the EQ5Dindex. The NTSS-6 provides a score of 0 to 3.66 in each of six domains. The score (range 0 to 21.96) is simply summed with zero meaning no symptoms. METHODS: A postal survey using various instruments including the NTSS-6 and the EQ5D was mailed to subjects identified at random as having either type-1 or Type-2 diabetes using the same methods as the Health Outcomes Data Repository (HODaR). Univariate and multivariate analysis were applied. This is a preliminary analysis of the first 604 returns. RESULTS: The mean age of respondents was 64 years (IQR 55–73); 58% were male and the mean duration of diabetes was 14 years (IQR 5–18). Of the 604 patients, 24% reported having no neuropathic symptoms. The overall mean (SD) EQ5Dindex was 0.65 (0.33), and mean NTSS- 6 score 6.2 (median and IQR 4.33, 1.0–10.33). In univariate analysis there was a direct association between the two instruments (correlation coefficient 0.57). Modeling the EQ5Dindex in multiple linear regression analysis to account for confounding, the NTSS-6 score was found to remain directly associated with utility, whereby an increase of one unit on the NTSS-6 resulted in as reduction in the EQ5Dindex of 0.029 units (p < 0.001). CONCLUSIONS: SDPN, as measured by the NTSS-6, were directly associated with health-related utility. After accounting for confounding factors, a unit change in the NTSS-6 was equivalent to a change in utility that is considered to be clinically meaningful.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Healthcare Sciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Blackwell Publishing
ISSN: 1098-3015
Last Modified: 04 Jun 2017 04:03

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