Daw, Abdulaziz E., Kazi, Hizbullah Ashhad, Colombo, John Samuel, Rowe, Wendy Gillian, Williams, David Wynne, Waddington, Rachel J., Thomas, David William and Moseley, Ryan 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28 (1) , pp. 144-160. 10.1177/0885328212441495 |
Abstract
This study investigated the effects of combined titanium nano-/micron-scale roughness, induced by hydrogen peroxide pre-treatments, on bone marrow stromal cell responses and Porphyromonas gingivalis adherence in vitro. Untreated surfaces exhibited nano-scale features, while hydrogen peroxide treatments promoted increased nano-/micron-scale roughness. Bone marrow stromal cell attachment and proliferation were maintained with 6 h and 24 h treatments, but significantly decreased on 1-week and 4-week-treated surfaces. Bone marrow stromal cells on 6 h-4 week-treated titanium demonstrated enhanced osteogenic differentiation versus untreated surfaces. P. gingivalis adherence was significantly increased on 24 h–4 week surfaces. Results suggest that 6 h but less than 24 h treatments maintain or promote bone marrow stromal cell responses while minimizing microbial adherence, potentially enhancing titanium surface bio-activation for osseointegration.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Dentistry Systems Immunity Research Institute (SIURI) |
Subjects: | Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RK Dentistry |
Uncontrolled Keywords: | Bone marrow stromal cell; hydrogen peroxide; osseointegration; osteoblast; peri-implantitis; surface roughness; titanium |
Publisher: | SAGE Publications |
ISSN: | 0885-3282 |
Last Modified: | 08 Mar 2020 17:23 |
URI: | http://orca.cf.ac.uk/id/eprint/31912 |
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