Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment

Daw, Abdulaziz E., Kazi, Hizbullah Ashhad, Colombo, John Samuel, Rowe, Wendy Gillian, Williams, David Wynne, Waddington, Rachel J., Thomas, David William and Moseley, Ryan 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28 (1) , pp. 144-160. 10.1177/0885328212441495

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Abstract

This study investigated the effects of combined titanium nano-/micron-scale roughness, induced by hydrogen peroxide pre-treatments, on bone marrow stromal cell responses and Porphyromonas gingivalis adherence in vitro. Untreated surfaces exhibited nano-scale features, while hydrogen peroxide treatments promoted increased nano-/micron-scale roughness. Bone marrow stromal cell attachment and proliferation were maintained with 6 h and 24 h treatments, but significantly decreased on 1-week and 4-week-treated surfaces. Bone marrow stromal cells on 6 h-4 week-treated titanium demonstrated enhanced osteogenic differentiation versus untreated surfaces. P. gingivalis adherence was significantly increased on 24 h–4 week surfaces. Results suggest that 6 h but less than 24 h treatments maintain or promote bone marrow stromal cell responses while minimizing microbial adherence, potentially enhancing titanium surface bio-activation for osseointegration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RK Dentistry
Uncontrolled Keywords:	Bone marrow stromal cell; hydrogen peroxide; osseointegration; osteoblast; peri-implantitis; surface roughness; titanium
Publisher:	SAGE Publications
ISSN:	0885-3282
Last Modified:	08 Mar 2020 17:23
URI:	http://orca.cf.ac.uk/id/eprint/31912

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