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Dectin-1 is required for beta-glucan recognition and control of fungal infection

Taylor, Philip Russel, Tsoni, S. Vicky, Willment, Janet A., Dennehy, Kevin M., Rosas, Marcela, Findon, Helen, Haynes, Ken, Steele, Chad, Botto, Marina, Gordon, Siamon and Brown, Gordon D. 2007. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nature Immunology 8 (1) , pp. 31-38. 10.1038/ni1408

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Abstract

Beta-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid receptor for -glucan, rendered mice susceptible to infection with Candida albicans. Dectin-1-deficient leukocytes demonstrated significantly impaired responses to fungi even in the presence of opsonins. Impaired leukocyte responses were manifested in vivo by reduced inflammatory cell recruitment after fungal infection, resulting in substantially increased fungal burdens and enhanced fungal dissemination. Our results establish a fundamental function for Beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
ISSN: 15292916
Last Modified: 03 Mar 2020 02:52
URI: http://orca.cf.ac.uk/id/eprint/320

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