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A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects

Tjalsma, Harold, Boleij, Annemarie, Marchesi, Julian Roberto and Dutilh, Bas E. 2012. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nature Reviews. Microbiology 10 (8) , pp. 575-582. 10.1038/nrmicro2819

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Abstract

Cancer has long been considered a genetic disease. However, accumulating evidence supports the involvement of infectious agents in the development of cancer, especially in those organs that are continuously exposed to microorganisms, such as the large intestine. Recent next-generation sequencing studies of the intestinal microbiota now offer an unprecedented view of the aetiology of sporadic colorectal cancer and have revealed that the microbiota associated with colorectal cancer contains bacterial species that differ in their temporal associations with developing tumours. Here, we propose a bacterial driver–passenger model for microbial involvement in the development of colorectal cancer and suggest that this model be incorporated into the genetic paradigm of cancer progression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Nature Publishing Group
ISSN: 1740-1526
Last Modified: 04 Jun 2017 04:04
URI: http://orca.cf.ac.uk/id/eprint/32096

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