Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex

Jacob, Vincent, Petreanu, Leopoldo, Wright, Nicholas Fraser, Svoboda, Karel and Fox, Kevin Dyson 2012. Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex. Neuron 73 (2) , pp. 391-404. 10.1016/j.neuron.2011.11.034

[img]
Preview
PDF
Download (1MB) | Preview

Abstract

Most functional plasticity studies in the cortex have focused on layers (L) II/III and IV, whereas relatively little is known of LV. Structural measurements of dendritic spines in vivo suggest some specialization among LV cell subtypes. We therefore studied experience-dependent plasticity in the barrel cortex using intracellular recordings to distinguish regular spiking (RS) and intrinsic bursting (IB) subtypes. Postsynaptic potentials and suprathreshold responses in vivo revealed a remarkable dichotomy in RS and IB cell plasticity; spared whisker potentiation occurred in IB but not RS cells while deprived whisker depression occurred in RS but not IB cells. Similar RS/IB differences were found in the LII/III to V connections in brain slices. Modeling studies showed that subthreshold changes predicted the suprathreshold changes. These studies demonstrate the major functional partition of plasticity within a single cortical layer and reveal the LII/III to LV connection as a major excitatory locus of cortical plasticity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Psychology
Subjects: Q Science > QH Natural history > QH301 Biology
Publisher: Elsevier
ISSN: 0896-6273
Funders: MRC, NIMH Conte Center
Last Modified: 04 Jun 2017 04:04
URI: http://orca.cf.ac.uk/id/eprint/32182

Citation Data

Cited 25 times in Google Scholar. View in Google Scholar

Cited 48 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 26 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item