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Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase

Kalinichenko, Svetlana V., Itoh, Keiji, Korobko, Elena V., Sokol, Sergei Y., Buchman, Vladimir L. and Korobko, Igor V. 2012. Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase. PLoS ONE 7 (6) , e39505. 10.1371/journal.pone.0039505

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Abstract

MAK-V/Hunk is a scantily characterized AMPK-like protein kinase. Recent findings identified MAK-V as a pro-survival and anti-apoptotic protein and revealed its role in embryonic development as well as in tumorigenesis and metastasis. However molecular mechanisms of MAK-V action and regulation of its activity remain largely unknown. We identified Nedd4 as an interaction partner for MAK-V protein kinase. However, this HECT-type E3 ubiquitin ligase is not involved in the control of MAK-V degradation by the ubiquitin-proteasome system that regulates MAK-V abundance in cells. However, Nedd4 in an ubiquitin ligase-independent manner rescued developmental defects in Xenopus embryos induced by MAK-V overexpression, suggesting physiological relevance of interaction between MAK-V and Nedd4. This identifies Nedd4 as the first known regulator of MAK-V function.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: PLoS
ISSN: 1932-6203
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 04:05
URI: http://orca.cf.ac.uk/id/eprint/32552

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Cited 2 times in Web of Science. View in Web of Science.

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