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Lesions of the basolateral amygdala disrupt conditioning based on the retrieved representations of motivationally significant events

Dwyer, Dominic M. and Killcross, Andrew Simon 2006. Lesions of the basolateral amygdala disrupt conditioning based on the retrieved representations of motivationally significant events. Journal of Neuroscience 26 (32) , pp. 8305-8309. 10.1523/JNEUROSCI.1647-06.2006

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Abstract

One recent perspective (Blundell et al., 2001; 2003; Killcross and Blundell, 2002; Balleine et al. 2003) on the function of the basolateral region of the amygdala (BLA) suggests that it plays an important role in the representation of the sensory features of motivationally significant events. This predicts that lesions of the BLA will not produce a decrement in performance in conditioning procedures based on the formation of associations between the sensory aspects of neutral events but will interfere with conditioning based on associations between neutral cues and motivationally significant events. This prediction is supported by the evidence that BLA lesions were without effect on a sensory preconditioning procedure (experiment 1A) that used neutral cues but that BLA lesions did significantly impair representation-mediated conditioning (experiment 1B) when the target cues were motivationally significant at the time of training. These results demonstrate that animals with lesions of the BLA can represent the sensory aspects of neutral events but not the sensory aspects of motivationally significant events.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: association; basolateral amygdala; mediated conditioning; classical conditioning; motivation; sensory preconditioning
Additional Information: “Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.(http://creativecommons.org/licenses/)” See: http://www.jneurosci.org/site/misc/ifa_policies.xhtml
Publisher: Society for Neuroscience
ISSN: 0270-6474
Last Modified: 17 Apr 2019 11:37
URI: http://orca.cf.ac.uk/id/eprint/3279

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