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Intramaze and extramaze cue processing in Tg2465 APPswe mutant mice

Barnes, Philip Andrew, Hale, Gemma and Good, Mark Andrew 2004. Intramaze and extramaze cue processing in Tg2465 APPswe mutant mice. Behavioral Neuroscience 118 (6) , pp. 1184-1195. 10.1037/0735-7044.118.6.1184

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The present study examined spatial and nonspatial learning in adult Tg2576 mice. Transgenic mice were impaired in acquisition of a T-maze forced-choice alternation task. However, mutant mice were as sensitive as control mice to the introduction of retention intervals and proactive interference, and this suggested that short-term memory processes were intact in Tg2576 mice. Probe trials revealed that the Tg2576 mice did not use an allocentric strategy to navigate to the goal arm. However, mutant mice acquired an intramaze brightness discrimination, a simple room discrimination, and a contextual biconditional left-right discrimination in a T maze. Results suggest that Tg2576 mice are able to process both intramaze and extramaze stimuli but are impaired in forming an allocentric representation of their environment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Psychological Association
ISSN: 0735-7044
Last Modified: 18 Oct 2017 10:58

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