Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Tract-specific anisotropy measurements in diffusion tensor imaging

Kanaan, Richard A., Shergill, Sukhwinder S., Barker, Gareth J., Catani, Marco, Ng, Virginia W., Howard, Robert, McGuire, Philip K. and Jones, Derek K. 2006. Tract-specific anisotropy measurements in diffusion tensor imaging. Psychiatry Research: Neuroimaging 146 (1) , pp. 73-82. 10.1016/j.pscychresns.2005.11.002

Full text not available from this repository.

Abstract

Diffusion tensor magnetic resonance imaging (DT-MRI) has been used to examine the microstructure of individual white matter tracts, often in neuropsychiatric conditions without identifiable focal pathology. However, the voxel-based group-mapping and region-of-interest (ROI) approaches used to analyse the data have inherent conceptual and practical difficulties. Taking the example of the genu of the corpus callosum in a sample of schizophrenic patients, we discuss the difficulties in attempting to replicate a voxel-based finding of reduced anisotropy using two ROI methods. Firstly we consider conventional ROIs; secondly, we present a novel tractography-based approach. The problems of both methods are explored, particularly of high variance and ROI definition. The potential benefits of the tractographic method for neuropsychiatric conditions with subtle and diffuse pathology are outlined.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Schizophrenia; DTI; Neuroimaging; Psychiatry
Publisher: Elsevier
ISSN: 0925-4927
Last Modified: 04 Jun 2017 04:07
URI: http://orca.cf.ac.uk/id/eprint/33022

Citation Data

Cited 145 times in Google Scholar. View in Google Scholar

Cited 135 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item