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Investigating the effect of exchange and multicomponentT1 relaxation on the short repetition time spoiled steady-state signal and the DESPOT1T1 quantification method

Deoni, Sean C. L., Rutt, Brian K. and Jones, Derek K. 2007. Investigating the effect of exchange and multicomponentT1 relaxation on the short repetition time spoiled steady-state signal and the DESPOT1T1 quantification method. Journal of Magnetic Resonance Imaging 25 (3) , pp. 570-578. 10.1002/jmri.20836

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Abstract

Purpose To examine the spoiled steady-state (spoiled gradient-recalled echo sequence [SPGR]) signal arising from two-compartment systems and the role of experimental parameters, in particular TR for resolving signal from each compartment. Materials and Methods Using Bloch-McConnell simulations, we examined the SPGR signal from two-component systems in which T1 is much greater than the mean residence time (τm) of proton spins in each component. Specifically, we examined the role of TR on the ability to resolve each components signal, as well as the influence of experimental parameters on derived DESPOT1 T1 values. Results Results revealed that when TR ≤ 0.01 τm, the measured SPGR signal may be modeled as a summation of signal from each species using a no-exchange approximation. Additionally, under this short TR condition, the driven equilibrium single pulse observation of T1 (DESPOT1) mapping approach provides T1 values preferentially biased toward the short or long T1 species, depending on the choice of flip angles. Conclusion The ability to model the SPGR signal using a no-exchange approximation may permit the quantification multicomponent T1 relaxation in vivo. Additionally, the ability to preferentially weight the DESPOT1 T1 value toward the short or long T1 may provide a useful window into these components.

Item Type: Article
Status: Published
Schools: Psychology
Uncontrolled Keywords: exchange; T1 mapping; multicomponent T1 relaxation; SPGR
Publisher: Wiley
ISSN: 1053-1807
Last Modified: 04 Jun 2017 04:07
URI: http://orca.cf.ac.uk/id/eprint/33025

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