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UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task

Humby, Trevor, Wilkinson, Lawrence Stephen and Dawson, Gerry 2005. UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. Current Protocols in Neuroscience, Chichester: Wiley, (10.1002/0471142301.ns0805hs31)

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Abstract

First developed in the 1980s by Trevor Robbins in Cambridge to investigate attentional function in rats, the 5-choice serial reaction time task involves continuous scanning by the subject across a spatial array of visual stimuli. On detecting a brief stimulus at one of five locations, the subject must make a nose poke in order to collect a reward. The task has also been conducted successfully in several strains of mice, including transgenic models. This unit presents the procedures required to run the task in mice, outlining the expected results at each stage of training and presenting examples of the most common manipulations used to dissociate behavior further.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Wiley
ISBN: 9780471142300
Related URLs:
Last Modified: 03 May 2019 08:03
URI: http://orca.cf.ac.uk/id/eprint/33031

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