Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory

Sanderson, David John, Gray, A., Simon, A., Taylor, A. M., Deacon, R. M. J., Seeburg, P. H., Sprengel, R., Good, Mark Andrew, Rawlins, J. N. P. and Bannerman, D. M. 2007. Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory. Behavioral Neuroscience 121 (3) , pp. 559-569. 10.1037/0735-7044.121.3.559

Full text not available from this repository.


Genetically modified mice lacking the glutamate receptor A (GluR-A) subunit of the AMPA receptor (GluR-A-/- mice) display normal spatial reference memory but impaired spatial working memory (SWM). This study tested whether the SWM impairment in these mice could be explained by a greater sensitivity to within-session proactive interference. The SWM performance of GluR-A-/- and wild-type mice was assessed during nonmatching-to-place testing under conditions in which potential proactive interference from previous trials was reduced or eliminated. SWM was impaired in GluR-A-/- mice, both during testing with pseudotrial-unique arm presentations on the radial maze and when conducting each trial on a different 3-arm maze, each in a novel testing room. Experimentally naive GluR-A-/- mice also exhibited chance performance during a single trial of spontaneous alternation. This 1-trial spatial memory deficit was present irrespective of the delay between the sample information and the response choice (0 or 45 min) and the length of the sample phase (0.5 or 5 min). These results imply that the SWM deficit in GluR-A-/- mice is not due to increased susceptibility to proactive interference.

Item Type: Article
Status: Published
Schools: Psychology
Publisher: American Psychological Association
ISSN: 0735-7044
Last Modified: 19 Dec 2017 04:07

Citation Data

Cited 60 times in Google Scholar. View in Google Scholar

Cited 72 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item