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Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study

Snoek, Heddeke, Van Goozen, Stephanie Helena Maria, Matthys, Walter, Sigling, Hein O., Koppeschaar, Hans P. F., Westernberg, Herman G. M. and Van Engeland, Herman 2002. Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study. Biological psychiatry 51 (4) , pp. 319-325. 10.1016/S0006-3223(01)01230-6

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Abstract

Background: Several studies support the notion that disturbances in the central serotonergic function are related to impulsive aggression. There is recent evidence from studies on 5-HT1B knock-out mice that this specific receptor is involved in impulsive aggressive behavior. The aim of the present study was to investigate 5-HT1B/1D receptor functioning in normal intelligent hospitalized children with oppositional defiant disorder (ODD). Methods: The growth hormone (GH) response to a challenge with the 5-HT1B/1D agonist sumatriptan was examined in 20 children with an ODD, of whom 13 had an attention-deficit/hyperactivity disorder comorbidity, and 15 normal control subjects (NC). Blood samples for growth hormone were collected repeatedly between 8:30 and 12:00 am. Sumatriptan was administered at 10 am. The effect of stress due to this procedure was assessed by measuring salivary cortisol. Results: The GH response was significantly stronger in the children with ODD. After sumatriptan injection NC children showed a significant increase in cortisol; no such pattern was present in the ODD group. Conclusions: The results suggest that the postsynaptic 5-HT1B/1D receptor is functionally more sensitive in children with ODD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Serotonin; aggression; sumatriptan; child psychiatry; 5-HT1B/1D receptors
Publisher: Elsevier
ISSN: 0006-3223
Last Modified: 04 Jun 2017 01:50
URI: http://orca.cf.ac.uk/id/eprint/3413

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