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Ordered growth of neurons on diamond

Specht, C. G., Williams, Oliver Aneurin, Jackman, R. B. and Schoepfer, R. 2004. Ordered growth of neurons on diamond. Biomaterials 25 (18) , pp. 4073-4078. 10.1016/j.biomaterials.2003.11.006

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Abstract

Diamond has a number of unique properties that make it an attractive electronic and bio-electronic material. Here we show the orderedgrowth of mammalian neurons, the principal electrogenic cells of the nervous system, on diamond. Proteins were specifically patterned on diamond surfaces by micro-contact printing. Mouse cortical neurons were then cultured on these substrates. Neuron adhesion and outgrowth was specific for those areas of the diamond that had been stamped with laminin, resulting in orderedgrowth of high resolution. Neurons survived in culture for the duration of the experiment, and laminin patterns were stable for at least 1 week in culture. The relative biocompatibility of diamond and the suitability of neuron interfacing with the hydrogen surface conductivity layer make this an interesting model for the formation of defined neuronal networks and for implants.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Physics and Astronomy
Subjects: Q Science > QC Physics
Uncontrolled Keywords: Biocompatibility; Diamond; Laminin; Micro-contact printing (μCP); Network; Neuron
Publisher: Elsevier
ISSN: 0142-9612
Last Modified: 04 Jun 2017 04:11
URI: http://orca.cf.ac.uk/id/eprint/34138

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