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Striatal activation during blepharospasm revealed by fMRI

Schmidt, K. E., Linden, David Edmund Johannes, Goebel, R., Zanella, F. E., Lanfermann, H. and Zubcov, A. A. 2003. Striatal activation during blepharospasm revealed by fMRI. Neurology 60 (11) , pp. 1738-1743. 10.1212/01.WNL.0000063306.67984.8C

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Objective: To investigate brain areas involved in the initiation and execution of eyelid spasm in patients with benign essential blepharospasm. Methods: The authors used fMRI and correlated the blood oxygenation level-dependent (BOLD) signal with epochs of frequent eyelid spasm in six patients and with epochs of voluntary eye blinks in four healthy subjects. Results: Spasm epochs were accompanied by activation in a subregion of the putamen in all patients, whereas voluntary blinking in healthy subjects was not. Other areas of activation common to patients and healthy subjects included frontal and parietal operculum, supplementary motor area, primary sensorimotor cortex, various visual areas, and the cerebellum. Conclusions: The striatum may be involved in the initiation or execution of eyelid spasm. Future studies, possibly including electromyography (EMG) during fMRI, are needed to detect the sequence and role of other concomitantly activated areas.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Academy of Neurology
ISSN: 0028-3878
Last Modified: 04 Jun 2017 04:13

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