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Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer's disease

Dierks, Thomas, Jelic, Vesna, Pascual-Marqui, Roberto D., Wahlund, Lars-Olof, Julin, Per, Linden, David Edmund Johannes, Maurer, Konrad, Winblad, Bengt and Nordberg, Agneta 2000. Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer's disease. Clinical Neurophysiology 111 (10) , pp. 1817-1824. 10.1016/S1388-2457(00)00427-2

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Abstract

Background: Since the measurement of human cerebral glucose metabolism (GluM) by positron emission tomography (PET) and that of human cerebral electrical activity by EEG reflect synaptic activity, both methods should be related in their cerebral spatial distribution. Healthy subjects do indeed demonstrate similar metabolic and neuroelectric spatial patterns. Objective: The aim of the study was to show that this similarity of GluM and EEG spatial patterns holds true in a population with a high variability of glucose metabolism. Methods: We investigated healthy control subjects and patients with varying degrees of cognitive dysfunction and varying GluM patterns by applying [18F]FDG PET and EEG. Results: We demonstrated that the localization of intracerebral generators of EEG correlates with spatial indices of GluM. Conclusion: These results indicates that EEG provides similar spatial information about brain function as GluM-PET. Since EEG is a non-invasive technique, which is more widely available and can be repeated more often than PET, this may have important implications both for neuropsychiatric research and for clinical diagnosis. However, further studies are required to determine whether equivalent EEG dipole generators can yield a diagnostic specificity and sensitivity similar to that of GluM-PET.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: EEG, PET, Glucose metabolism, Dipole, Alzheimer's disease, FFT-approximation
Publisher: Elsevier
ISSN: 1388-2457
Last Modified: 04 Jun 2017 04:13
URI: http://orca.cf.ac.uk/id/eprint/34801

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