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Exploring brain function with magnetic resonance imaging

Di Salle, F., Formisano, E., Linden, David Edmund Johannes, Goebel, R., Bonavita, S., Pepino, A., Smaltino, F. and Tedeschi, G. 1999. Exploring brain function with magnetic resonance imaging. European Journal of Radiology 30 (2) , pp. 84-94. 10.1016/S0720-048X(99)00047-9

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Since its invention in the early 1990s, functional magnetic resonance imaging (fMRI) has rapidly assumed a leading role among the techniques used to localize brain activity. The spatial and temporal resolution provided by state-of-the-art MR technology and its non-invasive character, which allows multiple studies of the same subject, are some of the main advantages of fMRI over the other functional neuroimaging modalities that are based on changes in blood flow and cortical metabolism. This paper describes the basic principles and methodology of fMRI and some aspects of its application to functional activation studies. Attention is focused on the physiology of the blood oxygenation level-dependent (BOLD) contrast mechanism and on the acquisition of functional time-series with echo planar imaging (EPI). We also provide an introduction to the current strategies for the correction of signal artefacts and other image processing techniques. In order to convey an idea of the numerous applications of fMRI, we will review some of the recent results in the fields of cognitive and sensorimotor psychology and physiology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Brain function, Magnetic resonance imaging, Non-invasive character
Publisher: Elsevier
ISSN: 0720-048X
Last Modified: 04 Jun 2017 04:13

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