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Does pretraining spare the spatial deficit associated with anterior thalamic damage in rats?

Warburton, E. C., Morgan, A., Baird, Alison Lambie, Muir, Janice L. and Aggleton, John Patrick 1999. Does pretraining spare the spatial deficit associated with anterior thalamic damage in rats? Behavioral Neuroscience 113 (5) , p. 956. 10.1037//0735-7044.113.5.956

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Abstract

Rats that had been pretrained on 2 tests of allocentric memory (water maze and T maze) received bilateral cytotoxic lesions in the anterior thalamic nuclei (ATN) or transection of the fimbria-fornix (FF). After surgery, both groups of rats were impaired on both tasks, although the preoperative training resulted in a rapid initial reacquisition of the water maze task. Those rats with lesions largely restricted to the ATN were impaired at a level comparable to that produced by FF lesions. This finding is consistent with a close functional relationship between the hippocampus and the ATN, necessary for the acquisition and on-line processing of allocentric spatial information but not for the maintenance/retrieval of procedural information. The rats with more extensive thalamic lesions were more impaired in both tasks and did show a loss of procedural information.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Psychological Association
ISSN: 0735-7044
Last Modified: 04 Jun 2017 04:13
URI: http://orca.cf.ac.uk/id/eprint/34927

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Cited 26 times in Web of Science. View in Web of Science.

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