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Mapping visual recognition memory through expression of the immediate early gene c-fos

Zhu, X. O., McCabe, B. J., Aggleton, John Patrick and Brown, M. W. 1996. Mapping visual recognition memory through expression of the immediate early gene c-fos. NeuroReport 7 (11) , pp. 1871-1875.

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To study brain regions involved in familiarity discrimination, rats were shown sets of novel and familiar objects. On each trial two objects were shown simultaneously to a rat so that one eye saw a novel object while the other saw a familiar object. Thus novel and familiar objects were seen with the same conditions of alertness and eye movements. Activated neurones were revealed by staining for products of the immediate early gene c-fos. Familiar stimuli activated significantly fewer neurones than novel stimuli in perirhinal cortex and area TE of temporal cortex, and the ventral lateral geniculate nucleus of the thalamus, but not in the hippocampus or other areas sampled. These findings are discussed in relation to recognition memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Learning, Memory, Recognition, Priming, IEGs, c-fos, Visual cortex, Amnesia, Rhinal cortex, Hippocampus, Prefrontal cortex, Thalamus, Rat
Publisher: Lippincott, Williams & Wilkins
ISSN: 0959-4965
Last Modified: 04 Jun 2017 04:13

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