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Selective cytotoxic lesions of the retrohippocampal region produce a mild deficit in social recognition memory

Bannerman, D., Lemaire, M., Yee, B., Iversen, S., Oswald, C., Good, Mark Andrew and Rawlins, J. 2002. Selective cytotoxic lesions of the retrohippocampal region produce a mild deficit in social recognition memory. Experimental Brain Research 142 (3) , pp. 395-401. 10.1007/s00221-001-0938-z

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Although a number of studies have implicated the hippocampal formation in social recognition memory in the rat, a recent study in this laboratory has demonstrated that selective cytotoxic lesions, confined to the hippocampus proper (encompassing the four CA subfields and the dentate gyrus), are without effect on this behaviour. This finding suggests that the hippocampus proper does not subserve social recognition memory in the rat, but does not preclude the possibility that other areas of the hippocampal formation, such as the entorhinal cortex or subiculum, could support this form of learning. The present study addressed this issue by examining the effects of selective cytotoxic retrohippocampal (RHR) lesions (including both the entorhinal cortex and subiculum) on social recognition memory in the rat. RHR lesions produced a mild social recognition memory impairment, although lesioned animals still displayed a reduction in investigation time between the first and second exposure to the juvenile. This result is consistent with other studies which have implicated the retrohippocampal or parahippocampal area in olfactory recognition memory processes. It also suggests, however, that other areas, outwith the retrohippocampal region, are also likely to play an important role in social recognition memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Hippocampal formation; Retrohippocampal region; Cytotoxic lesions; Social recognition; memory; Entorhinal cortex; Subiculum
Publisher: Springer
ISSN: 0014-4819
Last Modified: 04 Jun 2017 04:14

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