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Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems

Hall, F. S., Wilkinson, Lawrence Stephen, Humby, Trevor, Inglis, W., Kendall, D. A., Marsden, C. A. and Robbins, T. W. 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59 (4) , pp. 859-872. 10.1016/S0091-3057(97)00510-8

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Abstract

Isolationrearing of rats produces a behavioral syndrome indicative of altered dopamine (DA) function in the nucleus accumbens (NAC). The present experiments extend these findings by investigating: (a) interactions between isolationrearing and repeated handling/testing on presynaptic DA function in the NAC using in vivo microdialysis; (b) the dose–response curve for the effects of d-amphetamine, and the responses elicited by high potassium, using in vivo microdialysis; and (c) postsynaptic function in isolates as indexed by DA receptor-linked cAMP production. Experiment 1 showed that both isolationrearing and repeated handling/testing had effects on monoamine function in the NAC. However, while both manipulations enhanced DA release evoked by d-amphetamine, only isolated rats had elevated basal DA levels. Opposite neurochemical changes were observed with respect to the serotonin metabolite 5-HIAA, isolates having lower, and repeatedly handled/tested animals having higher, extracellular levels. Experiment 2 provided evidence for enhanced d-amphetamine–evoked DA release in isolated animals, while potassium-evoked DA release was reduced. Experiment 3 provided evidence that the isolationrearing induced changes in presynaptic DA function were accompanied by postsynapticchanges. Specifically, the inhibitory influence of the D2 receptor on D1 receptor-stimulated cAMP production was attenuated in ventral striatal slices taken from isolates, suggesting a functional downregulation of D2 receptors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Isolation rearing; Dopamine; Nucleus accumbens; In vivo microdialysis; cAMP
Publisher: Elsevier
ISSN: 0091-3057
Last Modified: 03 May 2019 08:05
URI: http://orca.cf.ac.uk/id/eprint/35360

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