Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex

Donev, Rossen Mintchev, Horton, Roger, Beck, Stephan, Doneva, Teodora, Vatcheva, Radost, Bowen, W. Richard and Sheer, Denise 2006. Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex. Journal of biological chemistry 278 (7) , pp. 5214-5226. 10.1074/jbc.M206621200

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Abstract

Sequences containing the matrix recognition signature were identified adjacent to the LMP/TAP gene cluster in the human and mouse major histocompatibility complex class II region. These sequences were shown to function as nuclear matrix attachment regions (MARs). Three of the five human MARs and the single mouse MAR recruit heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) in vivo during transcriptional up-regulation of the major histocompatibility complex class II genes. The timing of this recruitment correlates with a rise in mature TAP1 mRNA. Two of the human MARs bind hnRNP-A1 in vitro directly within a 35-bp sequence that shows over 90% similarity to certain Alu repeat sequences. This study shows that MARs recruit and bind hnRNP-A1 upon transcriptional up-regulation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Society for Biochemistry and Molecular Biology
ISSN:	00219258
Related URLs:	http://www.jbc.org/cgi/content/abstract/...
Last Modified:	19 Mar 2016 22:01
URI:	https://orca.cardiff.ac.uk/id/eprint/357

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