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Molecular interaction of recombinant decorin and biglycan with type 1 collagen influences crystal growth

Sugars, Rachael V., Milan, A. M., Brown, J. O., Waddington, Rachel J. and Embery, Graham 2003. Molecular interaction of recombinant decorin and biglycan with type 1 collagen influences crystal growth. Connective Tissue Research 44 (s1) , pp. 189-195.

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Abstract

This study has investigated the interaction of recombinant chondroitin sulphate (CS)-substituted decorin and biglycan on collagen fibrillogenesis, their interaction with hydroxyapatite (HAP), and HAP-induced crystal growth. The core proteins of the recombinant decorin and biglycan were obtained following chondroitinase ABC digestion and their influence on the above physical mechanisms were investigated in parallel. CS-decorin promoted collagen fibrillogenesis, with the interaction mediated principally through the core protein. Both decorin and biglycan demonstrated a strong association for HAP, predominately facilitated through the glycosaminoglycan chains. HAP-induced crystal growth was inhibited by decorin and biglycan, although the degree of inhibition was reduced when these proteoglycans were complexed with type I collagen. Thus, this study has highlighted potentially differing roles for decorin and biglycan, as both promoters and inhibitors in the regulation of the mineralization process.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > RK Dentistry
Publisher: Informa Healthcare
ISSN: 0300-8207
Last Modified: 04 Jun 2017 04:17
URI: http://orca.cf.ac.uk/id/eprint/36038

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