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Genetics of diabetic complications [Letter]

Alcolado, John 1998. Genetics of diabetic complications [Letter]. The Lancet 351 (9098) , pp. 230-231. 10.1016/S0140-6736(05)78278-7

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In 1965 Neel described diabetes mellitus as the “geneticist's nightmare”.1 Twin, family, and transracial studies suggested that inherited factors were important in the aetiology of the disease. It is now recognised that multiple genes, interacting with the environment, contribute to disease susceptibility. Despite the complexity of the picture, it has been possible to reduce the nightmare into just a “bad dream” by concentrating on specific subgroups of type 1 and type 2 diabetes. Thus in recent years the genes responsible for some cases of maturity-onset diabetes of the young (MODY),2–4 maternally inherited diabetes,5 and severe insulin resistance6 have been identified and several genome-wide searches have suggested possible loci for the more common forms of type 2 diabetes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0140-6736
Last Modified: 19 Mar 2016 23:02

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