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Long-term monitoring of the effects of thymoxamine hydrochloride tablets in the management of patients with Raynaud's disease

Aylward, Mansel, Bater, Penelope A., Davies, D. E., Dewland, P. M., Lewis, P. A. and Maddock, J. 1982. Long-term monitoring of the effects of thymoxamine hydrochloride tablets in the management of patients with Raynaud's disease. Current Medical Research and Opinion 8 (3) , pp. 158-170.

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Abstract

Seventeen patients with Raynaud's disease were followed whilst receiving treatment with 40 mg thymoxamine hydrochloride 4-times daily for periods ranging between 11 and 19 months. Digital artery patency and blood flow changes, assessed by Doppler ultrasound techniques after different thermal stresses, were monitored regularb as were platelet aggregation to ADP and collagen, platelet adhesion to glass beads. measures of blood coagulation and fibrinolysis, and plasma viscositey. Significant clinical improvement noted at 1 month appeared to improve further at 3 months and was maintained thereafter. Vessel patency rates at 10°C and 21°C improved significantly during treatment and both collagen-induced aggregation and platelet retention were significantly inhibited. These unexpected ejyects on platelet function are not readily explained by the drug's documented activity as a selective a-adrenergic antagonist and they may represent other hitherto unrecognized pharmacological effects which merit further exploration. The study also confirmed the usefulness of Doppler techniques for continuous atraumatic evaluation of digital vessel patency and investigation of therapeutic regimens on intermittent digital artery obstruction in Ravnaud's disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: thymoxamine, Raynaud's disease, digital artery patency
Publisher: Informa Healthcare
ISSN: 0300-7995
Last Modified: 04 Jun 2017 04:18
URI: http://orca.cf.ac.uk/id/eprint/36540

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