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Central Arterial Stiffness Occurs in Bronchiectasis [Abstract]

Gale, Nichola S., Duckers, James M., Munnery, Margaret, Enright, Stephanie, Cockcroft, John Ronald, Bolton, Charlotte Emma and Shale, Dennis 2009. Central Arterial Stiffness Occurs in Bronchiectasis [Abstract]. Artery Research 3 (4) , p. 159. 10.1016/j.artres.2009.10.173

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Abstract

Rationale: Bronchiectasis is characterised by inflammation and airways injury, which lead to loss of airways function, factors which are associated with an increased risk of cardiovascular disease (CVD) in various populations. Central arterial stiffness (AS) a predictor of CVD risk has not been studied in bronchiectasis. We hypothesised that patients with bronchiectasis would have increased AS. Methods: We studied 20 clinically stable patients with bronchiectasis and 20 age, sex and smoking matched controls, without evidence of CVD. In all subjects we determined FEV1, aortic pulse wave velocity (PWV), fasting lipids and systemic inflammation (IL-6). Results: Aortic PWV and IL-6 were greater in patients, than controls (p < 0.05), while age, BMI, lipids and MAP were similar for patients and controls. In all subjects age was the only predictor of aortic PWV (p < 0.01). Conclusions: Patients with bronchiectasis have increased AS, as determined by aortic PWV, which indicates an increased risk of CVD. Longer term studies are needed to determine the importance of this finding.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Postgraduate Medical and Dental Education
Healthcare Sciences
Subjects: R Medicine > RC Internal medicine
Publisher: Elsevier
ISSN: 1872-9312
Last Modified: 11 Oct 2018 20:54
URI: http://orca.cf.ac.uk/id/eprint/36585

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