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Experience-dependent regulation of functional maps and synaptic protein expression in the cat visual cortex

Jaffer, Sajjida, Vorobyov, V., Kind, P. C. and Sengpiel, Frank 2012. Experience-dependent regulation of functional maps and synaptic protein expression in the cat visual cortex. European Journal of Neuroscience 35 (8) , pp. 1281-1294. 10.1111/j.1460-9568.2012.08044.x

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Abstract

Although the basis of our knowledge of experience-dependent plasticity comes from studies on carnivores and primates, studies examining the physiological and molecular mechanisms that underlie development and plasticity have increasingly employed mice. We have used several common rearing paradigms, such as dark-rearing and monocular deprivation (MD), to examine the timing of the physiological and molecular changes to altered experience in the cat primary visual cortex. Dark-rearing from birth or for 1 week starting at 4 weeks of age produced a similar reduction in the amplitude of responses measured through intrinsic signal imaging and a reduction in orientation selectivity. One week of visual experience following dark-rearing until 4 weeks of age yielded normal responses in both amplitude and orientation selectivity. The depression of deprived-eye responses was similar in magnitude after 2 and 7 days of MD. In contrast, non-deprived-eye responses almost doubled in magnitude after 7 days compared with 2 days of MD. These changes in the functional properties of primary visual cortex neurons were mirrored by specific changes in synaptic protein expression. Changes in proteins such as the NR2A and NR2B subunits of the N-methyl-D-aspartate receptor, postsynaptic density protein 95, alpha-CA2+/calmodulin-dependent protein kinase II (αCaMKII), and GABAAα1a indicated that the levels of sensory activity regulated mechanisms associated with both excitatory (NR2A and NR2B) and inhibitory (GABAAα1a) transmission so as to maintain response homeostasis. Additionally, we found that MD regulated the AMPA receptor glutamate (GluR1) subunit as well as signalling molecules (αCaMKII and synaptic Ras GTPase activating protein, SynGAP) downstream of N-methyl-D-aspartate receptors. Proteins in a common signalling pathway appeared to have similar developmental expression profiles that were broadly similar between cats and rodents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > Q Science (General)
Q Science > QL Zoology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: GABA receptors; glutamate receptors; ocular dominance; optical imaging; orientation selectivity
Publisher: Wiley-Blackwell
ISSN: 0953-816X
Last Modified: 02 May 2019 11:45
URI: http://orca.cf.ac.uk/id/eprint/37848

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