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Management and outcome of bloodstream infections due to Candida species in England and Wales

Kibbler, C. C., Seaton, S., Barnes, Rosemary Ann, Gransden, W. R., Holliman, R. E., Johnson, E. M., Perry, J. D., Sullivan, D. J. and Wilson, J. A. 2003. Management and outcome of bloodstream infections due to Candida species in England and Wales. Journal of Hospital Infection 54 (1) , pp. 18-24. 10.1016/S0195-6701(03)00085-9

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This two-year prospective hospital population-based study of candidaemia is the first to be conducted in the UK. It was carried out on behalf on the British Society for Medical Mycology (BSMM) as part of the European Confederation of Medical Mycology (ECMM) epidemiological survey of candidaemia. Six hospitals in England and Wales acted as sentinel hospitals. Main outcome measures were hospital population-based incidence and 30-day mortality. There were 18.7 episodes of candidaemia per 100 000 finished consultant episodes or 3.0/100 000 bed days and 45.4% cases occurred in intensive care unit (ICU) patients. Candida albicans was isolated in 64.7% of confirmed cases. The majority of isolates were sensitive to standard antifungal agents, including fluconazole. The overall 30-day mortality was 26.4% and removal of the central venous catheter was associated with a significant reduction in mortality. In conclusion, the incidence of candidaemia in England and Wales is similar to that of the USA, the majority of isolates remain sensitive to commonly used antifungal agents and mortality associated with this infection appears to be falling.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Candidaemia; Candida albicans; Bloodstreaminfections; Epidemiology; Mortality; Antifungal therapy
Publisher: Elsevier
ISSN: 0195-6701
Last Modified: 04 Jun 2017 04:26

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