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Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial

Welton, Joanne, Morgan, Matthew, Martí, Salvador, Stone, Michael, Moser, Bernhard, Sewell, Andrew K., Turton, Jane and Eberl, Matthias 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28 (3) , pp. 464-471. 10.1002/jbmr.1797

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Abstract

Aminobisphosphonates (NBPs) are used widely against excessive bone resorption in osteoporosis and Paget’s disease as well as in metastatic bone disease and multiple myeloma. Intravenous NBP administration often causes mild to severe acute phase responses (APRs) that may require intervention with analgesics and antipyretics and lead to treatment noncompliance and non-adherence. We here undertook a phase IV safety trial in patients with osteoporosis to investigate the APR of otherwise healthy individuals to first-time intravenous treatment with the NBP zoledronate. This study provides unique insight into sterile acute inflammatory responses in vivo, in the absence of confounding factors such as infection or cancer. Our data show that both peripheral

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: AminobiSsphosphonates; γδ T cells; acute-phase response; osteoporosis; immunotherapy
Publisher: American Society for Bone and Mineral Research
ISSN: 0884-0431
Date of First Compliant Deposit: 30 March 2016
Last Modified: 13 Nov 2017 01:25
URI: http://orca.cf.ac.uk/id/eprint/41413

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