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Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy

Pertusati, Fabrizio, Serpi, Michaela and McGuigan, Christopher 2011. Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy. Antiviral Chemistry and Chemotherapy 22 (5) , pp. 181-203. 10.3851/IMP2012

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Abstract

Considerable attention has been focused on the development of phosphonate-containing drugs for application in many therapeutic areas. However, phosphonate diacids are deprotonated at physiological pH and thus phosphonate-containing drugs are not ideal for oral administration, an extremely desirable requisite for the treatment of chronic diseases. To overcome this limitation several prodrug structures of biologically active phosphonate analogues have been developed. The rationale behind the design of such agents is to achieve temporary blockade of the free phosphonic functional group until their systemic absorption and delivery, allowing the release of the active drug only once at the target. In this paper, an overview of acyclic and cyclic nucleoside phosphonate prodrugs, designed as antiviral agents, is presented.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Nucleus Global
ISSN: 2040-2066
Date of First Compliant Deposit: 30 March 2016
Last Modified: 10 Oct 2017 23:22
URI: http://orca.cf.ac.uk/id/eprint/41440

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