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Association at SYNE1 in both bipolar disorder and recurrent major depression

Green, Elaine Karen, Grozeva, Detelina Valentinova, Forty, Elizabeth, Gordon-Smith, K., Russell, Elen, Farmer, A., Hamshere, Marian Lindsay, Jones, Ian Richard, Jones, L., McGuffin, P., Moran, J. L., Purcell, S., Sklar, P., Owen, Michael John, O'Donovan, Michael Conlon and Craddock, Nicholas John 2013. Association at SYNE1 in both bipolar disorder and recurrent major depression. Molecular Psychiatry 18 , pp. 614-617. 10.1038/mp.2012.48

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Abstract

Genome-wide association studies (GWAS) have identified a number of loci that have strong support for their association with bipolar disorder (BD). The Psychiatric Genome-Wide Association Study (GWAS) Consortium Bipolar Disorder Working Group (PGC-BD) meta-analysis of BD GWAS data sets and replication samples identified evidence (P=6.7 × 10−7, odds ratio (OR)=1.147) of association with the risk of BD at the polymorphism rs9371601 within SYNE1, a gene which encodes nesprin-1. Here we have tested this polymorphism in an independent BD case (n=1527) and control (n=1579) samples, and find evidence for association (P=0.0095) with similar effect sizes to those previously observed in BD (allelic OR=1.148). In a combined (meta) analysis of PGC-BD data (both primary and replication data) and our independent BD samples, we found genome-wide significant evidence for association (P=2.9 × 10−8, OR=1.104). We have also examined the polymorphism in our recurrent unipolar depression cases (n=1159) and control (n=2592) sample, and found that the risk allele was associated with risk for recurrent major depression (P=0.032, OR=1.118). Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: SYNE1, bipolar disorder, unipolar depression, genetics, rs9371601
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 13 Jan 2018 20:28
URI: http://orca.cf.ac.uk/id/eprint/41476

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