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Preliminary μSR studies on the incorporation of steroidal drug molecules into liposomes

Barker, S. A., Cottrell, S. P., Giblin, Sean and Jayasooriya, U. A. 2006. Preliminary μSR studies on the incorporation of steroidal drug molecules into liposomes. Physica B: Condensed Matter 374 , pp. 332-335. 10.1016/j.physb.2005.11.089

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Abstract

Muon spin relaxation of two liposome samples consisting of 100% DPPC (dipalmitoylphosphatidylcholine) and 50:50 mole% DPPC:Cholesterol at a final lipid concentration of 100 mg/mL are compared. The observation of a significant loss in the muonium fraction from 11% to 6% when cholesterol is present is compatible with radical formation in the second sample. Also reported are measurements on pure solid cholesterol where a clear T1 minimum at ca 100 K, corresponding to a dynamic process with activation energy of ca. 1.89 kJ mol−1 and an attempt frequency of 5.89×1010 s−1, is observed. An estimate of a hyperfine interaction of 255.4 MHz for this radical predicts a ΔM=1 ALC transition at 0.94 T.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Physics and Astronomy
Subjects: Q Science > QC Physics
Uncontrolled Keywords: Drug delivery; Liposomes; Steroids; Spin resonance
Additional Information: Proceedings of the Tenth International Conference on Muon Spin Rotation, Relaxation and Resonance
Publisher: Elsevier
ISSN: 0921-4526
Last Modified: 04 Jun 2017 04:36
URI: http://orca.cf.ac.uk/id/eprint/41492

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