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A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division

Cruz-Ramirez, Alfredo, Diaz-Trivino, Sara, Blilou, Ikram, Grieneisen, Veronica A., Sozzani, Rosangela, Zamioudis, Christos, Miskolczi, Pal, Nieuwland, Jeroen, Benjamins, Rene, Dhonukshe, Pankaj, Caballero-Perez, Juan, Horvath, Beatrix, Long, Yuchen, Mahonen, Ari Pekka, Zhang, Hongtao, Xu, Jian, Murray, James Augustus Henry, Benfey, Philip N., Bako, Laszlo, Maree, Athanasius F. M. and Scheres, Ben 2012. A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division. Cell 150 (5) , pp. 1002-1015. 10.1016/j.cell.2012.07.017

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Abstract

In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOMA-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a “flip flop” that constrains asymmetric cell division to the stem cell region.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QK Botany
Publisher: Elsevier (Cell Press)
ISSN: 0092-8674
Last Modified: 13 Feb 2019 15:45
URI: http://orca.cf.ac.uk/id/eprint/41599

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