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DNA Mismatch Detection by Resonance Energy Transfer between Ruthenium(II) and Osmium(II) Tris(2,2‘-bipyridyl) Chromophores

Bichenkova, Elena V., Yu, Xuan, Bhadra, Pranab, Heissigerova, Helena, Pope, Simon J. A., Coe, Benjamin J., Faulkner, Stephen and Douglas, Kenneth T. 2005. DNA Mismatch Detection by Resonance Energy Transfer between Ruthenium(II) and Osmium(II) Tris(2,2‘-bipyridyl) Chromophores. Inorganic Chemistry 44 (12) , pp. 4112-4114. 10.1021/ic050586w

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Abstract

Octahedral tris-chelate complexes [MII(bpy)3]2+ (M = Ru or Os, bpy = 2,2‘-bipyridyl), covalently attached to the 3‘- and 5‘-phosphates of two oligonucleotides, are juxtaposed when hybridized contiguously to a fully complementary DNA target. Visible metal-to-ligand charge-transfer (MLCT) excitation of the [RuII(bpy)3]2+ unit leads to resonance energy transfer to the MLCT state of the [OsII(bpy)3]2+ moiety, with the energy transfer efficiency depending on the degree of hybridization. The extent of attenuation of the intense red luminescence from the RuII chromophore hence allows highly sensitive structural probing of the assembly and constitutes a novel approach to DNA sensing which is capable of detecting mutations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
ISSN: 0020-1669
Last Modified: 04 Jun 2017 04:37
URI: http://orca.cf.ac.uk/id/eprint/41634

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