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Producing striatal phenotypes for transplantation in Huntington's disease

Precious, Sophie Victoria and Rosser, Anne Elizabeth 2012. Producing striatal phenotypes for transplantation in Huntington's disease. Experimental Biology and Medicine 237 (4) , pp. 343-351. 10.1258/ebm.2011.011359

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Abstract

Neural transplantation as a therapeutic strategy in neurodegenerative disorders offers to replace cells lost during the disease process, with the potential to reconstruct dysfunctional circuitry, thus alleviating associated disease symptoms. The focal loss of striatal cells, specifically medium-sized spiny neurons (MSN) in Huntington's disease (HD), makes transplantation a therapeutic option. Here, we review the progress made in generating striatal MSN phenotypes for transplantation in HD. We discuss the use of primary fetal tissue as a donor source in both preclinical and clinical studies and assess the options for renewable cell sources. We evaluate progress in directing the differentiation of renewable cells towards a striatal MSN phenotype for HD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Huntington's disease; medium-sized spiny neurons; neural transplantation; primary fetal tissue; embryonic stem cells
Publisher: The Society of Experimental Biology and Medicine
ISSN: 1535-3702
Last Modified: 10 Oct 2017 14:52
URI: http://orca.cf.ac.uk/id/eprint/41732

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