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Targeted inactivation of the gene encoding gamma-synuclein affects anxiety levels and investigative activity in mice

Kokhan, V. S., Bolkunov, A. V., Ustiugov, A. A., Van'kin, G. I., Shelkovnikova, Tatyana, Redkozubova, O. M., Strekalova, T. V., Buchman, Vladimir L., Ninkina, Natalia and Bachurin, S. O. 2012. Targeted inactivation of the gene encoding gamma-synuclein affects anxiety levels and investigative activity in mice. Neuroscience and Behavioral Physiology 42 (6) , pp. 575-581. 10.1007/s11055-012-9603-1

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Abstract

Gamma (γ) synuclein is a member of the family of synucleins, which are cytoplasmic, predominantly, neuronal, proteins found only in vertebrates. Significant quantities of γ-synuclein are found in the axons and presynaptic terminals of neurons located in brain areas responsible for forming emotions and memory. However, the involvement of γ-synucleins in controlling neuronal and synaptic processes underlying various types of behavior in humans and animals have not yet been studied. We provide the first demonstration that the absence of γ-synuclein increases orientational-investigative activity in a novel context and decreases the level of situational anxiety in animals.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Springer
ISSN: 0097-0549
Last Modified: 11 Apr 2019 22:13
URI: http://orca.cf.ac.uk/id/eprint/41844

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