Beltrami, Cristina, Clayton, Aled, Phillips, Aled Owain, Fraser, Donald James and Bowen, Timothy 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40 (4) , pp. 875-879. 10.1042/BST20120090 |
Abstract
Kidney biopsy is the gold-standard diagnostic test for intrinsic renal disease, but requires hospital admission and carries a 3% risk of major complications. Current non-invasive prognostic indicators such as urine protein quantification have limited predictive value. Better diagnostic and prognostic tests for chronic kidney disease patients are a major focus for industry and academia, with efforts to date directed largely at urinary proteomic approaches. microRNAs constitute a recently identified class of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Systems Immunity Research Institute (SIURI) |
Subjects: | R Medicine > R Medicine (General) |
Uncontrolled Keywords: | biomarker, chronic kidney disease (CKD), exosome, microRNA (miRNA), urine |
Publisher: | Biochemical Society |
ISSN: | 0300-5127 |
Last Modified: | 11 Apr 2019 22:15 |
URI: | http://orca.cf.ac.uk/id/eprint/41949 |
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