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Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer

Kasraee, Behrooz, Nikolic, Damjan S., Salomon, Denis, Carraux, Pierre, Fontao, Lionel, Piguet, Vincent, Omrani, Gholamhossein R., Sorg, Olivier and Saurat, Jean-Hilaire 2012. Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer. Experimental Dermatology 21 (1) , pp. 19-24. 10.1111/j.1600-0625.2011.01394.x

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Abstract

We assessed the ability of ebselen, a glutathione peroxidase mimic, to reduce pigmentation in various models. In murine B16 melanocytes, 25 μm ebselen inhibited melanogenesis and induced a depolymerisation of actin filaments. In co-cultures of B16 melanocytes with BDVII keratinocytes, a pretreatment of melanocytes with ebselen resulted in a strong inhibition of melanosome transfer to keratinocytes, as shown under optical and electron microscopy. In reconstructed epidermis, topical 0.5% ebselen led to a twofold decrease of melanin without affecting the density of active melanocytes. A similar result was obtained with topical 0.5% ebselen in black guinea pig ears. Ebselen induced a decrease of epidermal melanin parallel to a localisation of melanin and melanosomes in the basal layer. Ebselen appears as a new depigmenting compound that inhibits melanin synthesis and melanosome transfer to keratinocytes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RL Dermatology
Uncontrolled Keywords: ebselen, hydrogen peroxide, keratinocytes, melanocytes, pigmentation
Publisher: Wiley-Blackwell
ISSN: 0906-6705
Last Modified: 04 Jun 2017 04:39
URI: http://orca.cf.ac.uk/id/eprint/42209

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