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Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF

Anghel, Silvia I., Correa-Rochal, Rafael, Budinska, Eva, Boliganl, Kayluz F., Abraham, Shahnaz, Colombetti, Sara, Fontao, Lionel, Mariotti, Agnese, Rimoldi, Donata, Ghanem, Ghanem E., Fisher, David E., Lévy, Frederic, Delorenzi, Mauro and Piguet, Vincent 2012. Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF. Pigment Cell & Melanoma Research 25 (4) , pp. 482-487. 10.1111/j.1755-148X.2012.01018.x

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Abstract

Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MM–derived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: human, melanoma, potential biomarker, BCSC-1, tumor suppressor, MITF, proliferation
Publisher: Wiley-Blackwell
ISSN: 1755-1471
Last Modified: 04 Jun 2017 04:39
URI: http://orca.cf.ac.uk/id/eprint/42317

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