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Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an achromobacter xylosoxidans strain isolated in Tripoli, Libya

El Salabi, Allaaeddin, Borra, P. S., Toleman, Mark Alexander Howard, Samuelsen, O. and Walsh, Timothy Rutland 2012. Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an achromobacter xylosoxidans strain isolated in Tripoli, Libya. Antimicrobial Agents and Chemotherapy 56 (5) , pp. 2241-2245. 10.1128/AAC.05640-11

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Abstract

An Achromobacter xylosoxidans strain from the Tripoli central hospital produced a unique metallo-β-lactamase, designated TMB-1, which is related to DIM-1 (62%) and GIM-1 (51%). blaTMB-1 was embedded in a class 1 integron and located on the chromosome. The TMB-1 β-lactamase has lower kcat values than both DIM-1 and GIM-1 with cephalosporins and carbapenems. The Km values were more similar to those of GIM-1 than those of DIM-1, with the overall kcat/Km values being lower than those for GIM-1 and DIM-1.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0066-4804/ (accessed 24/02/2014)
Publisher: American Society for Microbiology
ISSN: 0066-4804
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 04:39
URI: http://orca.cf.ac.uk/id/eprint/42324

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