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Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods

Oertel-Knöchel, Viola, Reinke, Britta, Hornung, Alexandra, Knöchel, Christian, Matura, Silke, Knopf, Monika, Prvulovic, David, O'Dwyer, Laurence, Lindner, Michael, Rau, Alexandra, Hampel, Harald, Haenschel, Corinna and Linden, David Edmund Johannes 2012. Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods. Journal of Nervous and Mental Disease 200 (4) , pp. 296-304. 10.1097/NMD.0b013e31824ceef7

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Abstract

This is the first study to combine psychometric and functional neuroimaging methods to study altered patterns of autobiographical memory in bipolar disorder (BD). All participants were interviewed with an expanded version of the Bielefelder Autobiographical Memory Inventory (Bielefelder Autobiographisches Gedächtnis Inventar 2004;Lisse: Swets and Zeitlinger). We then acquired functional magnetic resonance imaging data during a task of individually designed autobiographical recall. Compared with healthy controls, BD patients reported a stronger emotionality of autobiographical memories and more frequent recollections of autobiographical events during their everyday life. Furthermore, they failed to deactivate areas in the cuneus and lingual gyrus and showed decreased activation in the inferior frontal and precentral areas compared with the control group. More frequent intrusions from a person's past, which had a neural correlate in the lack of deactivation in some default mode network areas in BD patients, may contribute to manic or depressive symptoms

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Lippincott, Williams & Wilkins
ISSN: 1539-736X
Last Modified: 04 Jun 2017 04:40
URI: http://orca.cf.ac.uk/id/eprint/42700

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