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New insights into the preparation of the low-melting polymorph of racemic ibuprofen

Williams, Philip Andrew, Hughes, Colan Evan and Harris, Kenneth David Maclean 2012. New insights into the preparation of the low-melting polymorph of racemic ibuprofen. Crystal Growth and Design 12 (12) , pp. 5839-5845. 10.1021/cg300599q

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Abstract

Recently, a second crystalline polymorph (Form II) of racemic ibuprofen was reported to be obtained by crystallization from the supercooled liquid state. The reported procedure involved a temperature schedule that included the requirement to quench the sample to a temperature (168 K) significantly below the glass-transition temperature (228 K) followed by annealing at a temperature (typically 258 K) above the glass-transition temperature. In the present work, we show (by differential scanning calorimetry and in situ, variable-temperature powder X-ray diffraction) that Form II of racemic ibuprofen can be prepared by crystallization from the supercooled liquid at temperatures as high as 273 K, without the requirement for low-temperature quenching and without the requirement for the material to pass below the glass-transition temperature. Our results lead to a new interpretation of the experimental conditions for producing Form II of racemic ibuprofen and remove racemic ibuprofen from the set of crystalline materials that are obtained only via low-temperature quenching of a supercooled liquid.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
ISSN: 1528-7483
Last Modified: 08 May 2019 02:27
URI: http://orca.cf.ac.uk/id/eprint/42881

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